Year 2022 / Volume 29 / Supplement 1

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Cannabinoids Article

Medical cannabis treatment in patients with visceral chronic pain

Rev. Soc. Esp. Dolor. 2022; 29(13): 32-42 / DOI: 10.20986/resed.2022.4030/2022

Raquel Abalo, Jesús de Santiago


ABSTRACT

Chronic visceral pain is very common and disabling. Chronic secondary visceral pain must be distinguished from chronic primary visceral pain states that are considered diseases in their own right. Primary chronic visceral pain is a category of nociplastic-like pain, characterized by impaired nociception without clear evidence of actual or potential tissue damage. Management of primary chronic visceral pain is challenging, either due to lack of pharmacological efficacy or intolerance to side effects. In this context, treatment with cannabinoids can be a useful alternative in these patients.
In this review, after briefly explaining the pathophysiological mechanisms involved in chronic visceral pain and its relationship with the endocannabinoid system, we will show the current evidence on the use of cannabinoids in the treatment of chronic visceral pain.



RESUMEN

El dolor visceral crónico es muy frecuente e incapacitante. El dolor visceral secundario crónico debe distinguirse de los estados de dolor visceral primario crónico, que se consideran enfermedades por derecho propio. El dolor visceral crónico primario es una categoría del dolor de tipo nociplástico, que se caracteriza por una nocicepción alterada sin evidencia clara de daño tisular real o potencial.
El manejo del dolor visceral crónico primario es un desafío, ya sea por falta de eficacia farmacológica o por intolerancia de los efectos secundarios. En este contexto, el tratamiento con cannabinoides puede ser una alternativa útil en estos pacientes.
En esta revisión, tras explicar brevemente los mecanismos fisiopatológicos implicados en el dolor visceral crónico y su relación con el sistema endocannabinoide, revisaremos la evidencia actual sobre la utilización de cannabinoides en el tratamiento del dolor crónico visceral.





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Instrucciones para citar

Abalo R, de Santiago J. Medical cannabis treatment in patients with visceral chronic pain. Rev Soc Esp Dolor 2022; 29(13): 32-42 / DOI: 1020986/resed20224030/2022


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Aceptado: 20/09/2022

Publicado: 28/10/2022


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