Year 2023 / Volume 30 / Number 2

Review

Pharmacogenetics in analgesic response: towards a sex-differences personalized medicine

Rev. Soc. Esp. Dolor. 2023; 30(2): 115-124 / DOI: 10.20986/resed.2023.4042/2022

Beatriz Orts, Javier Muriel, Ana María Peiró


ABSTRACT

Chronic pain is a silent epidemic, affecting 1 in 5 adults in Europe. This fact coexists with the abuse of analgesic drugs by some patients, a circumstance that is limiting their prescription in chronic non-cancer pain. The challenge would be to be able to select the people who, a priori, would have a better analgesic response based on a series of intrinsic conditions. This review analyzes the differences based on sex and the presence of certain variants in the genes that encode the mu opioid receptor (OPRM1), the cytochrome metabolizing enzyme CYP2D6 and the catechol-O-methyltransferase (COMT) that degrades catecholamines. The objective is to provide potentially explanatory elements that can guide the clinical professional in the selection of a more personalized analgesia.



RESUMEN

El dolor crónico supone una epidemia silenciosa que afecta a 1 de cada 5 personas adultas en Europa. Este hecho convive con el abuso que realizan algunos pacientes de los medicamentos analgésicos, circunstancia que está limitando su prescripción en el dolor crónico no oncológico. El reto sería poder seleccionar las personas que, a priori, tendrían una mejor respuesta analgésica en base a una serie de condicionamientos intrínsecos. La presente revisión analiza las diferencias en base al sexo y a la presencia de ciertas variantes en los genes que codifican el receptor opioide mu (OPRM1), la enzima metabolizadora del citocromo CYP2D6 y la catecol-O-metiltransferasa (COMT) que degrada catecolaminas. El objetivo es suministrar potenciales elementos explicativos que puedan orientar al profesional clínico en la selección de una analgesia más personalizada.





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Bibliografía

1. Langley PC, Ruiz-Iban MA, Molina JT, De Andres J, Castellón JR. The prevalence, correlates and treatment of pain in Spain. J Med Econ.2011;14(3):367-80.
2. Pérez C, Margarit C, Serrano M. Survey of European patients assessing their own noncancer chronic pain: results from Spain. Curr Med Res Opin. 2013;29(6):643-51.
3. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL, 3rd. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain. 2009;10(5):447-85.
4. Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Br J Anaesth. 2013;111(1):52-8.
5. Darnall BD, Stacey BR, Chou R. Medical and psychological risks and consequences of long-term opioid therapy in women. Pain Med. 2012;13(9):1181-211.
6. Planelles B, Margarit C, Inda MD, Ballester P, Muriel J, Barrachina J, et al. Gender based differences, pharmacogenetics and adverse events in chronic pain management. Pharmacogen J. 2020;20(2):320-8.
7. Hutchinson K, Moreland AM, de CWAC, Weinman J, Horne R. Exploring beliefs and practice of opioid prescribing for persistent non-cancer pain by general practitioners. Eur J Pain. 2007;11(1):93-8.
8. Ballina J, Carmona L, Laffon A. Impacto del consumo de AINE en la población general española. Resultados del estudio EPISER. Rev Esp Reumatol. 2002;29(7):337-42.
9. Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, Davies P, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009;10(2):113-30.
10. Larsson B, Dragioti E, Grimby-Ekman A, Gerdle B, Björk J. Predictors of chronic pain intensity, spread, and sensitivity in the general population: A two-year follow-up study from the SWEPAIN cohort. J Rehabil Med. 2019;51(3):183-92.
11. Canadian Institutes of Health Research. Science is better with sex and gender. 2018.
12. Pisanu C, Franconi F, Gessa GL, Mameli S, Pisanu GM, Campesi I, et al. Sex differences in the response to opioids for pain relief: A systematic review and meta-analysis. Pharmacol Res. 2019;148:104447.
13. Gallach Solano E, Bermejo Gómez MA, Robledo Algarra R, Izquierdo Aguirre RM, Canos Verdecho MA. Determinantes de género en el abordaje del dolor crónico. Rev Soc Esp Dolor. 2020;27(4):252-6.
14. Kiely KM, Brady B, Byles J. Gender, mental health and ageing. Maturitas. 2019;129:76-84.
15. Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, et al. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015;18(8):1081-3.
16. Samulowitz A, Gremyr I, Eriksson E, Hensing G. “Brave Men” and “Emotional Women”: A Theory-Guided Literature Review on Gender Bias in Health Care and Gendered Norms towards Patients with Chronic Pain. Pain Res Manag. 2018;2018:6358624.
17. Richardson J, Holdcroft A. Gender differences and pain medication. Women's health (London, England). 2009;5(1):79-90.
18. Sex, Hormones & Genetics Affect Brain's Pain Control System. ScienceDaily. 2003.
19. Saiz-Rodríguez M, Ochoa D, Herrador C, Belmonte C, Román M, Alday E, et al. Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects. Basic Clin Pharmacol Toxicol. 2019;124(3):321-9.
20. Manubay J, Davidson J, Vosburg S, Jones J, Comer S, Sullivan M. Sex differences among opioid-abusing patients with chronic pain in a clinical trial. J Addict Med. 2015;9(1):46-52.
21. Muriel J, Margarit C, Barrachina J, Ballester P, Flor A, Morales D, et al. Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients. Basic Clin Pharmacol Toxicol. 2019;124(4):439-48.
22. Mónica Escorial JM, Jordi Barrachina, César Margarit, Laura Agulló, Ana María Peiró. Efectividad a largo plazo de la deprescripción en pacientes con dependencia a opioides: farmacogenética con perspectiva de sexo. Rev Soc Esp Dolor. (En Prensa) 2021.
23. Lopes GS, Bielinski S, Moyer AM, Jacobson DJ, Wang L, Jiang R, et al. Sex differences in type and occurrence of adverse reactions to opioid analgesics: a retrospective cohort study. BMJ open. 2021;11(6):e044157.
24. Serdarevic M, Striley CW, Cottler LB. Sex differences in prescription opioid use. Current opinion in psychiatry. 2017;30(4):238-46.
25. Back SE, Payne RA, Waldrop AE, Smith A, Reeves S, Brady KT. Prescription opioid aberrant behaviors: a pilot study of sex differences. Clin J Pain. 2009;25(6):477-84.
26. Holgado D, Manresa-Rocamora A, Zamboni L, Lugoboni F, Peiró AM, Zandonai T. The effect of benzodiazepines on exercise in healthy adult participants: A systematic review. J Addict Dis.2021:1-9.
27. McHugh RK, Geyer RB, Chase AR, Griffin ML, Bogunovic O, Weiss RD. Sex differences in benzodiazepine misuse among adults with substance use disorders. Addict Behav. 2021;112:106608.
28. McLean CP, Anderson ER. Brave men and timid women? A review of the gender differences in fear and anxiety. Clin Psychol Rev. 2009;29(6):496-505.
29. Gemmati D, Varani K, Bramanti B, Piva R, Bonaccorsi G, Trentini A, et al. “Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era. Int J Mol Sci. 2019;21(1):296.
30. Sato H, Droney J, Ross J, Olesen AE, Staahl C, Andresen T, et al. Gender, variation in opioid receptor genes and sensitivity to experimental pain. Mol Pain. 2013;9:20.
31. Cabaleiro T, Ochoa D, Román M, Moreno I, López-Rodríguez R, Novalbos J, et al. Polymorphisms in CYP2D6 have a greater effect on variability of risperidone pharmacokinetics than gender. Basic Clin Pharmacol Toxicol. 2015;116(2):124-8.
32. Muriel J, Margarit C, Planelles B, Serralta MJ, Puga C, Inda MD, et al. OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients. Ann N Y Acad Sci. 2018;1425(1):82-93.
33. Campbell CI, Weisner C, Leresche L, Ray GT, Saunders K, Sullivan MD, et al. Age and gender trends in long-term opioid analgesic use for noncancer pain. Am J Public Health. 2010;100(12):2541-7.
34. Back SE, Lawson KM, Singleton LM, Brady KT. Characteristics and correlates of men and women with prescription opioid dependence. Addict Behav. 2011;36(8):829-34.
35. Back SE, Payne RL, Simpson AN, Brady KT. Gender and prescription opioids: findings from the National Survey on Drug Use and Health. Addict Behav. 2010;35(11):1001-7.
36. Aloisi AM. Why We Still Need To Speak About Sex Differences and Sex Hormones in Pain. Pain Ther. 2017;6(2):111-4.
37. Vázquez-Santiago S, Garrido Peña F. El enfoque de género en las necesidades de atención sociosanitaria. Enferm Clín. 2016;26(1):76-80.
38. Organización Panamericana de la Salud. GÉNERO Y SALUD: una Guía Práctica para la Incorporación de la Perspectiva de Género en Salud; 2010.
39. Guideline on good pharmacogenomic practice. European Medicines Agency: Committee for Medicinal Products for Human Use (CHMP); 2018.
40. Table of Pharmacogenomic Biomarkers in Drug Labeling [Internet]. U.S. Food and Drug Administration; 2020. Disponible en: https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling
41. Lin YS, Thummel KE, Thompson BD, Totah RA, Cho CW. Sources of Interindividual Variability. Methods Mol Biol. 2021;2342:481-550.
42. Alomar MJ. Factors affecting the development of adverse drug reactions (Review article). Saudi Pharm J. 2014;22(2):83-94.
43. Roden DM, McLeod HL, Relling MV, Williams MS, Mensah GA, Peterson JF, et al. Pharmacogenomics. Lancet. 2019;394(10197):521-32.
44. Crews KR, Monte AA, Huddart R, Caudle KE, Kharasch ED, Gaedigk A, et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. Clin Pharmacol Ther. 2021;110(4):888-96.
45. Somogyi AA, Coller JK, Barratt DT. Pharmacogenetics of opioid response. Clin Pharmacol Ther. 2015;97(2):125-7.
46. Reynolds KK, Ramey-Hartung B, Jortani SA. The value of CYP2D6 and OPRM1 pharmacogenetic testing for opioid therapy. Clin Lab Med. 2008;28(4):581-98.
47. Benjeddou M, Peiró AM. Pharmacogenomics and prescription opioid use. Pharmacogenomics. 2021;22(4):235-45.
48. Kwon AH, Flood P. Genetics and Gender in Acute Pain and Perioperative Opioid Analgesia. Anesthesiol Clin. 2020;38(2):341-55.
49. Chou WY, Yang LC, Lu HF, Ko JY, Wang CH, Lin SH, et al. Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty. Acta Anaesthesiol Scand. 2006;50(7):787-92.
50. Mague SD, Isiegas C, Huang P, Liu-Chen LY, Lerman C, Blendy JA. Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proc Natl Acad Sci U S A. 2009;106(26):10847-52.
51. Liu A, Zhang H, Qin F, Wang Q, Sun Q, Xie S, et al. Sex Associated Differential Expressions of the Alternatively Spliced Variants mRNA of OPRM1 in Brain Regions of C57BL/6 Mouse. Cell Physiol Biochem. 2018;50(4):1441-59.
52. Collins D, Zhang Y, Blendy J, Kreek MJ. Murine model of OPRM1 A118G alters oxycodone self-administration and locomotor activation, but not conditioned place preference. Neuropharmacol. 2020;167:107864.
53. Reyes-Gibby CC, Shete S, Rakvag T, Bhat SV, Skorpen F, Bruera E, et al. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain. 2007;130(1-2):25-30.
54. Meloto CB, Bortsov AV, Bair E, Helgeson E, Ostrom C, Smith SB, et al. Modification of COMT-dependent pain sensitivity by psychological stress and sex. Pain. 2016;157(4):858-67.
55. Smith HS. Opioid metabolism. Mayo Clin Proc. 2009;84(7):613-24.
56. He ZX, Chen XW, Zhou ZW, Zhou SF. Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine. Drug Metab Rev. 2015;47(4):470-519.
57. Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, Leeder JS. The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clin Pharmacol Ther. 2008;83(2):234-42.
58. Naranjo ME, de Andrés F, Delgado A, Cobaleda J, Peñas-Lledó EM, A LL. High frequency of CYP2D6 ultrarapid metabolizers in Spain: controversy about their misclassification in worldwide population studies. Pharmacogenomics J. 2016;16(5):485-90.
59. Matic M, de Wildt SN, Tibboel D, van Schaik RHN. Analgesia and Opioids: A Pharmacogenetics Shortlist for Implementation in Clinical Practice. Clin Chem. 2017;63(7):1204-13.
60. Owusu Obeng A, Hamadeh I, Smith M. Review of Opioid Pharmacogenetics and Considerations for Pain Management. Pharmacotherapy. 2017;37(9):1105-21.
61. Gray K, Adhikary SD, Janicki P. Pharmacogenomics of analgesics in anesthesia practice: A current update of literature. J Anaesthesiol Clin Pharmacol. 2018;34(2):155-60.
62. Linares OA, Daly D, Linares AD, Stefanovski D, Boston RC. Personalized oxycodone dosing: using pharmacogenetic testing and clinical pharmacokinetics to reduce toxicity risk and increase effectiveness. Pain Med. 2014;15(5):791-806.
63. Naito T, Takashina Y, Yamamoto K, Tashiro M, Ohnishi K, Kagawa Y, et al. CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone. J Clin Pharmacol. 2011;51(11):1529-38.
64. Stamer UM, Zhang L, Book M, Lehmann LE, Stuber F, Musshoff F. CYP2D6 genotype dependent oxycodone metabolism in postoperative patients. PloS one. 2013;8(3):e60239.
65. Andreassen TN, Eftedal I, Klepstad P, Davies A, Bjordal K, Lundstrom S, et al. Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study. Eur J Clin Pharmacol. 2012;68(1):55-64.
66. Balyan R, Mecoli M, Venkatasubramanian R, Chidambaran V, Kamos N, Clay S, et al. CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients. Pharmacogenomics. 2017;18(4):337-48.
67. Dagostino C, Allegri M, Napolioni V, D'Agnelli S, Bignami E, Mutti A, et al. CYP2D6 genotype can help to predict effectiveness and safety during opioid treatment for chronic low back pain: results from a retrospective study in an Italian cohort. Pharmgenomics Pers Med. 2018;11:179-91.
68. Slanar O, Dupal P, Matouskova O, Vondrackova H, Pafko P, Perlik F. Tramadol efficacy in patients with postoperative pain in relation to CYP2D6 and MDR1 polymorphisms. Bratisl Lek Listy.2012;113(3):152-5.
69. Wu SB, Cai LN, Yang XH, Fu HG, Sun K, Yuan F, et al. Impact of CYP2D6 Polymorphisms on Postoperative Fentanyl Analgesia in Gastric Cancer Patients. Genet Test Mol Biomarkers. 2015;19(5):248-52.
70. Stauble ME, Moore AW, Langman LJ, Boswell MV, Baumgartner R, McGee S, et al. Hydrocodone in postoperative personalized pain management: pro-drug or drug? Clin Chim Acta. 2014;429:26-9.
71. Mactier H, McLaughlin P, Gillis C, Osselton MD. Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers. Am J Perinatol. 2017;34(9):918-21.
72. Park HJ, Choi YJ, Kim JW, Chun HS, Im I, Yoon S, et al. Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes. PloS one. 2015;10(7):e0132992.
73. Rostam-Abadi Y, Gholami J, Amin-Esmaeili M, Safarcherati A, Mojtabai R, Ghadirzadeh MR, et al. Tramadol use and public health consequences in Iran: a systematic review and meta-analysis. Addiction. 2020;115(12):2213-42.
74. Schelde AB, Sørensen AMS, Hindsø M, Christensen MB, Jimenez-Solem E, Eriksson R. Sex and age differences among tramadol users in three Nordic countries. Dan Med J. 2020;67(7).
75. Zandonai T, Escorial M, Peiró AM. Codeine and Tramadol Use in Athletes: A Potential for Abuse. Front Pharmacol. 2021;12:661781.
76. Buynak R, Shapiro DY, Okamoto A, Hove IV, Rauschkolb C, Steup A, et al. Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo-and active-controlled Phase III study. Expert Opin Pharmacother. 2010;11(11):1787-804.
77. Hartrick CTJEoop. Tapentadol immediate release for the relief of moderate-to-severe acute pain. Expert Opin Pharmacother. 2009;10(16):2687-96.
78. Viñas-Bastart M, Oms-Arias M, Pedraza-Gutiérrez À, Lizano-Díez I, Mariño EL, Modamio P. Tapentadol and Oxycodone/Naloxone Prescribing Patterns in Primary Health Care in Catalonia, Spain: A Cross-Sectional Study. Risk Manag Healthc Policy. 2021;14:4155-68.
79. Barrachina J, Margarit C, Muriel J, López-Gil S, López-Gil V, Vara-González A, et al. Oxycodone/naloxone versus tapentadol in real-world chronic non-cancer pain management: an observational and pharmacogenetic study. Sci Rep. 2022;12(1):10126.
80. Elder NM, Atayee RS, Best BM, Ma JD. Observations of urinary oxycodone and metabolite distributions in pain patients. J Anal Toxicol. 2014;38(3):129-34.

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Opioid tapering may improve outcomes for chronic pain patients

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Myofascial pain syndrome as a cause of postoperative acute pain in hip surgery

Rev. Soc. Esp. Dolor. 2019; 26(2): 117-119 / DOI: 10.20986/resed.2019.3655/2018

Effectiveness of hand crossing to produce analgesia in patients with chronic pain of the upper limb

Rev. Soc. Esp. Dolor. 2019; 26(2): 81-88 / DOI: 10.20986/resed.2019.3674/2018

Opioids and addiction in chronic pain: is it a problem?, how to address it?

Rev. Soc. Esp. Dolor. 2019; 26(2): 65-67 / DOI: 10.20986/resed.2019.3736/2019

Oxytocin and chronic pain in humans

Rev. Soc. Esp. Dolor. 2019; 26(1): 52-58 / DOI: 10.20986/resed.2018.3664/2018

Radiofrequency thermal and splanchnics nerves block

Rev. Soc. Esp. Dolor. 2018; 25(5): 303-304 / DOI: 10.20986/resed.2016.3509/2016

Implications of bioethics in the treatment of chronic pain: the change of paradigms

Rev. Soc. Esp. Dolor. 2018; 25(5): 291-300 / DOI: 10.20986/resed.2018.3666/2018

Pain in the elderly and in patients with cognitive deficit. A DELPHI study

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Chrono study: prevalence of breakthrough pain among patients with non-cancer chronic pain in Andalusia, Spain

Rev Soc Esp Dolor 2018; 25(4): 214-221 / DOI: 10.20986/resed.2017.3626/2017

Sex and pain: sexual satisfaction and sexual function in a sample of patients with chronic, non-pelvic pain

Rev Soc Esp Dolor 2018; 25(3): 145-154 / DOI: 10.20986/resed.2018.3600/2017

Painometer v2®: a mobile application certified for monitoring patients with pain

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Potential uses of Mirtazapine in palliative care beyond its antidepressant effect

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Chronic pain: relationship with prefrontal symptoms and perceived stress

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Prevalence of breakthrough pain associated with chronic low back pain in Andalusia (COLUMBUS study)

Rev Soc Esp Dolor 2017; 24(3):116-124 / DOI: 10.20986/resed.2017.3548/2016

Instrucciones para citar

Orts B, Muriel J, Peiró A. Pharmacogenetics in analgesic response: towards a sex-differences personalized medicine. Rev Soc Esp Dolor 2023; 30(2): 115-124 / DOI: 1020986/resed20234042/2022


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Recibido: 16/11/2022

Aceptado: 26/05/2023

Prepublicado: 08/06/2023

Publicado: 20/09/2023

Tiempo de revisión del artículo: 190 días

Tiempo de prepublicación: 204 días

Tiempo de edición del artículo: 308 días


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