Year 2024 / Volume 31 / Number 1

Review

Predisposing factors for chronic post-surgical pain. Narrative review

Rev. Soc. Esp. Dolor. 2024; 31(1): 32-39 / DOI: 10.20986/resed.2024.4131/2024

Patricia Bonilla, Paula Elizabeth Quizhpe, Carolina Suárez


ABSTRACT

The pain that occurs after surgery and that persists for more than 3 months is one of the complications that has the most repercussions on the quality of life and psychological well-being of the patient, as well as representing a significant expense for the health system, the knowledge of its triggers is key to its prevention and effective approach. This narrative review was carried out with the objective of determining the predisposing factors for the development of post-surgical chronic pain, after conducting a search in the databases PubMed, SCOPUS and Google Scholar, using DeCS and MeSH terms, 27 were the articles selected for further analysis, the types of surgery that covered them, were mainly general, gynecological and thoracic surgery. As results, it was obtained that the factors related to the development of pain were: age, physical condition and comorbidities, expectations regarding pain, surgical technique and its duration, the presence or absence of acute pain after surgery, use of postoperative analgesia and recently investigated genetic polymorphisms.



RESUMEN

El dolor que se presenta posterior a la cirugía, y que persiste más de 3 meses, es una de las complicaciones que más repercusiones tiene en la calidad de vida y bienestar psicológico del paciente además de representar un gasto importante para el sistema de salud. El conocimiento de sus desencadenantes es clave para la prevención y el abordaje efectivo del mismo. Esta revisión narrativa se llevó a cabo con el objetivo de determinar los factores predisponentes para el desarrollo de dolor crónico postquirúrgico, después de realizar una búsqueda en las bases de datos, PubMed, SCOPUS y Google Scholar, mediante términos DeCS y MeSH; 27 fueron los artículos seleccionados para su posterior análisis. Los tipos de cirugía que abarcaron los mismos fueron cirugía general, ginecológica y torácica, principalmente. Como resultados, se obtuvieron que los factores relacionados con el desarrollo de dolor fueron la edad, estado físico y comorbilidades, expectativas respecto al dolor, técnica quirúrgica y su duración, la presencia o no de dolor agudo posterior a la cirugía, uso de analgesia postoperatoria y recientemente investigados polimorfismos genéticos.





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Bibliografía

1. Schug SA, Lavand’Homme P, Barke A, Korwisi B, Rief W, Treede RD. The IASP classification of chronic pain for ICD-11: Chronic postsurgical or posttraumatic pain. Pain. 2019;160(1):45-52.
2. Willingham MD, Vila MR, ben Abdallah A, Avidan MS, Haroutounian S. Factors Contributing to Lingering Pain after Surgery: The Role of Patient Expectations. Anesthesiology. 2021;134(6):915-24.
3. Wang Y, Liu Z, Chen S, Ye X, Xie W, Hu C, et al. Pre-surgery beliefs about pain and surgery as predictors of acute and chronic post-surgical pain: a prospective cohort study. Int J Surg. 2018;52:50-55.
4. Fletcher D, Lavand'homme P. Towards better predictive models of chronic post-surgical pain: fitting to the dynamic nature of the pain itself. Br J Anaesth. 2022;129(3):281-4.
5. Lu Y, Hu B, Dai H, Wang B, Yao J, Yao X. Predictors of chronic postsurgical pain in elderly patients undergoing hip arthroplasty: a multi-center retrospective cohort study. Int J Gen Med. 2021;14:7885-94.
6. Shu B, Xu F, Zheng X, Zhang Y, Liu Q, Li S, et al. Change in perioperative neutrophil-lymphocyte ratio as a potential predictive biomarker for chronic postsurgical pain and quality of life: an ambispective observational cohort study. Front Immunol. 2023;14:1177285.
7. Willingham M, Rangrass G, Curcuru C, ben Abdallah A, Wildes TS, McKinnon S, et al. Association between postoperative complications and lingering post-surgical pain: an observational cohort study. Br J Anaesth. 2020;124(2):214-21.
8. Núñez-Cortés R, Chamorro C, Ortega-Palavecinos M, Mattar G, Paredes O, Besoaín-Saldaña Á, et al. Social determinants associated to chronic pain after total knee arthroplasty. Int Orthop. 2019;43(12):2767-71.
9. Tian M, Li Z, Chen X, Wu Q, Shi H, Zhu Y, et al. Prevalence and predictors of chronic pain with two-year follow-up after knee arthroplasty. J Pain Res. 2022;15:1091-105.
10. Edgley C, Hogg M, de Silva A, Braat S, Bucknill A, Leslie K. Severe acute pain and persistent post-surgical pain in orthopaedic trauma patients: a cohort study. Br J Anaesth. 2019;123(3):350-9.
11. Zhang Y, Zhou R, Hou B, Tang S, Hao J, Gu X, et al. Incidence and risk factors for chronic postsurgical pain following video-assisted thoracoscopic surgery: a retrospective study. BMC Surg. 2022;22(1):1-8.
12. Tian Y, Liu X, Jia M, Yu H, Lichtner P, Shi Y, et al. Targeted Genotyping Identifies Susceptibility Locus in Brain-derived Neurotrophic Factor Gene for Chronic Postsurgical Pain. Anesthesiology. 2018;128(3):587-97.
13. Jin J, Chen Q, Min S, Du X, Zhang D, Qin P. Prevalence and predictors of chronic postsurgical pain after colorectal surgery: a prospective study. Colorectal Dis. 2021;23(7):1878-89.
14. Fiorelli S, Cioffi L, Menna C, Ibrahim M, De Blasi R, Rendina E, et al. Chronic pain after lung resection: risk factors, neuropathic pain, and quality of life. J Pain Symptom Manage. 2020;60(2):326-35.
15. Buvanendran A, Della Valle C, Kroin J, Shah M, Moric M, Tuman K, et al. Acute postoperative pain is an independent predictor of chronic postsurgical pain following total knee arthroplasty at 6 months: a prospective cohort study. Reg Anesth Pain Med. 2019;44(3):e100036.
16. Gong Y, Tan Q, Qin Q, Wei C. Prevalence of postmastectomy pain syndrome and associated risk factors: A large single-institution cohort study. Medicine (Baltimore). 2020;99(20):e19834.
17. Bayman E, Parekh K, Keech J, Selte A, Brennan T. A Prospective Study of Chronic Pain after Thoracic Surgery. Anesthesiology. 2017;126(5):938-51.
18. Benlolo S, Hanlon, J, Shirreff L, Lefebvre G, Husslein H, Shore, E. Predictors of Persistent Postsurgical Pain After Hysterectomy-A Prospective Cohort Study. J Minim Invasive Gynecol. 2021;28(12):2036-2046.e1.
19. Tan H, Sultana R, Han NL, Tan CW, Sia AT, Sng BL. The Association Between Preoperative Pain Catastrophizing and Chronic Pain After Hysterectomy - Secondary Analysis of a Prospective Cohort Study. J Pain Res. 2020;13:2151-62.
20. Pinto P, McIntyre T, Araújo-Soares V, Almeida A, Costa P. Psychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study on chronic postsurgical pain. Pain. 2018;159(5):956-67.
21. Jin J, Zhang T, Xiong X, Chen H, Jiang Y, He S. A prospective study of chronic postsurgical pain in elderly patients: incidence, characteristics and risk factors. BMC Geriatr. 2023;23(1):289.
22. Costelloe C, Burns S, Yong R, Kaye A, Urman R. An Analysis of Predictors of Persistent Postoperative Pain in Spine Surgery. Curr Pain Headache Rep. 2020;24(4):11.
23. Yin Y, Zhang L, Xiao H, Wen CB, Dai YE, Yang G, et al. The pre-amputation pain and the postoperative deafferentation are the risk factors of phantom limb pain: a clinical survey in a sample of Chinese population. BMC Anesthesiol. 2017;17(1):69.
24. Giordano N, Kane A, Jannace K, Rojas W, Lindl M, Lujan E, et al. Discrete and dynamic postoperative pain catastrophizing trajectories across 6 months: a prospective observational study. Arch Phys Med Rehabil. 2020;101(10):1754-62.
25. Dürsteler C, Salazar Y, Rodriguez U, Pelfort X, Verdié LP. Conditioned pain modulation predicts persistent pain after knee replacement surgery. Pain Rep. 2021;6(1):e910.
26. Harrogate SR, Cooper JA, Zawadka M, Anwar S. Seven-year follow-up of persistent postsurgical pain in cardiac surgery patients: A prospective observational study of prevalence and risk factors. Eur J Pain. 2021;25(8):1829-38.
27. Van Reij RR, Hoofwijk DM, Rutten BP, Weinhold L, Leber M, Joosten EA, et al. The association between genome-wide polymorphisms and chronic postoperative pain: a prospective observational study. Anaesthesia. 2020;75 Suppl 1(Suppl 1):e111-e120.
28. Sluka K, Wager T, Sutherland S, Labosky P, Balach T, Bayman E, et al. Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures. Pain. 2023;164(9):1912-26.

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Instrucciones para citar

Bonilla P, Quizhpe P, Suárez C. Predisposing factors for chronic post-surgical pain. Narrative review. Rev Soc Esp Dolor 2024; 31(1): 32-39 / DOI: 1020986/resed20244131/2024


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Recibido: 09/02/2024

Aceptado: 29/09/2024

Prepublicado: 10/12/2024

Publicado: 22/01/2025

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