Keywords
symptomatic treatment
pain
occupational medicine
occupational health
survey.
Abstract
Goals: To know the use of migraine crisis symptomatic treatments in different countries of Europe and the differences observed depending on social and demographic variables. Material and methods: Cross-sectional observational study by anonymous web survey to 3,342 patients from Spain, Italy, France, Portugal, Ireland, United Kingdom, Germany and other countries of the European Union. Study variables: age, gender, country, type of location, level of studies and rural or urban area. The symptomatic treatments that are collected are: simple analgesics, non-steroidal anti-inflammatory drugs, triptans, other treatments, several treatments, without treatment, ignorance of symptomatic treatment. Results: For simple analgesics, the largest consumers are between 41-60 years (p < 0.0001). Spain and Germany are the countries with the highest use (p < 0.0001). For the anti-inflammatories, the greatest use is between 21-60 years (p < 0.0001). Spain, Italy and Germany are the countries that make the most use of them (p < 0.0001) and higher consumption in patients with higher education (p < 0.003). Triptans use shows a relationship with age and gender, greater use between 21-60 years (p < 0.0001) and in women (p < 0.0001). By countries, the highest sintomáconsumption is in Germany, the rest of the European Union countries, Spain and the United Kingdom (p < 0.0001). Greater consumption in patients living in cities with more than 500 inhabitants (p < 0.010) and with medium or higher studies (p < 0.0001). In the group of middle and upper studies, we find, by contrast, the highest percentage of patients who do not know what a symptomatic treatment is (p < 0.0001). Conclusions: The result varies according each country greatly and they are modified depending on different social and demographic conditions, being the age, gender, rural or urban environment and cultural level the factors that most affect the use of each symptomatic medication for the migraine crisis.References
1. Katsarava Z, Mania M, Lampl C, Herberhold J, Steiner TJ. Poor medical care for people with migraine in Europe - evidence from the Eurolight study. J Headache Pain. 2018;19(1):10. DOI: 10.1186/s10194-018-0839-1.
2. Martelletti P, Schwedt TJ, Lanteri-Minet M, Quintana R, Carboni V, Diener HC, et al. My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed. J Headache Pain. 2018;19(1):115. DOI: 10.1186/s10194-018-0946-z.
3. Vo P, Fang J, Bilitou A, Laflamme AK, Gupta S. Patients perspective on the burden of migraine in Europe: a cross-sectional analysis of survey data in France, Germany, Italy, Spain, and the United Kingdom. J Headache Pain. 2018;19(1):82. DOI: 10.1186/s10194-018-0907-6.
4. Brandes JL. Global trends in migraine care: results from the MAZE survey. CNS Drugs. 2002;16 Suppl 1:13-8. DOI: 10.2165/00023210-200216001-00003.
5. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. DOI: 10.1177/0333102417738202.
6. Sociedad española de neurología. Guía Oficial de práctica clínica en Cefaleas. Comité del Grupo de estudio de cefaleas SEN. 2015. Disponible en: cefaleas.sen.es/pdf/GUIA_NEURO_2015.pdf. Consultado el 13/05/2019.
7. Mathew S, Ailani J. Traditional and Novel Migraine Therapy in the Aging Population. Curr Pain Headache Rep. 2019;23(6):42. DOI: 10.1007/s11916-019-0789-6.
8. Brusa P, Allais G, Rolando S, Baratta F, Giaccone M, Bussone G, et al. Migraine attacks in the pharmacy: a gender subanalysis on treatment preferences. Neurol Sci. 2015;36 Suppl 1:93-5. DOI: 10.1007/s10072-015-2156-7.
9. Medrano Martínez V, Callejo Domínguez JM, Beltrán Lasco I, Pérez Carmona N, Abellán Miralles I, González Caballero G, et al. Migraine education brochures and patient-perceived satisfaction. Neurologia. 2015;30(8):472-8. DOI: 10.1016/j.nrl.2014.04.010.
10. Douthit N, Kiv S, Dwolatzky T, Biswas S. Exposing some important barriers to health care access in the rural USA. Public Health. 2015;129(6):611-20. DOI: 10.1016/j.puhe.2015.04.001.
11. Lin SW, Yen CF, Chiu TY, Chi WC, Liou TH. New indices for home nursing care resource disparities in rural and urban areas, based on geocoding and geographic distance barriers: a cross-sectional study. Int J Health Geogr. 2015;14:28. DOI: 10.1186/s12942-015-0021-9.
12. Grazzi L, Grignani E, D'Amico D, Sansone E, Raggi A. Is Medication Overuse Drug Specific or Not? Data from a Review of Published Literature and from an Original Study on Italian MOH Patients. Curr Pain Headache Rep. 2018;22(11):71. DOI: 10.1007/s11916-018-0729-x.
13. Brandes JL, Buchanan TM, Welch KM. Acute treatment of migraine. Handb Clin Neurol. 2010;97:323-36. DOI: 10.1016/S0072-9752(10)97026-7.
14. Csépány É, Magyar M, Gyüre T, Bozsik G, Ertsey C. Current pharmacotherapy in migraine. Neuropsychopharmacol Hung. 2015;17(4):169-76.
15. Cameron C, Kelly S, Hsieh SC, Murphy M, Chen L, Kotb A, et al. Triptans in the Acute Treatment of Migraine: A Systematic Review and Network Meta-Analysis. Headache. 2015;55 Suppl 4:221-35. DOI: 10.1111/head.12601.
16. Tajti J, Majláth Z, Szok D, Csáti A, Vécsei L. Drug safety in acute migraine treatment. Expert Opin Drug Saf. 2015;14(6):891-909. DOI: 10.1517/14740338.2015.1026325.