Keywords
ibuprofeno intravenoso
dolor postoperatorio
cuidados perioperatorios
anti-inflamatorios no esteroideos
Abstract
El dolor postoperatorio de intensidad alta o extrema, tiene una incidencia publicada cercana al 30% de los pacientes quirúrgicos, siendo su principal preocupación, incluso más relevante que los resultados satisfactorios o no que pudiera tener el procedimiento en la resolución de su enfermedad. Los AINEs son los fármacos más prescritos en el mundo para el tratamiento del dolor agudo y crónico de diferentes causas. Ibuprofeno es un analgésico ampliamente utilizado en la prevención y tratamiento del dolor. Recientemente su forma intravenosa ha sido aprobada por la FDA (www.accessdata.fda.gov) para el tratamiento del dolor leve a moderado y moderado a severo complementario a la analgesia opioide. Adicionalmente, ha sido aprobado para la reducción de fiebre. Dado su potencial como adyuvante en la analgesia multimodal, se realizó una revisión acerca del uso perioperatorio del ibuprofeno intravenoso, analizando la literatura disponible en inglés y español en PubMed y Ovid MEDLINE hasta diciembre 2015. Se incluyeron datos farmacocinéticos y farmacodinámicos provenientes de pacientes de diferentes edades, así como estudios clínicos, incluyendo aquellos en los que se cuantificó el uso de opioides en el periodo postoperatorio, analizando la sinergia entre ambos tipos de analgésicos. Ibuprofeno intravenoso ofrece ventajas sobre la presentación oral siendo una alternativa a la limitada disponibilidad de AINEs endovenosos como parte de la analgesia multimodal perioperatoria.References
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